REVIEW ARTICLE


microRNA-146a: A Biomarker for Epileptogenesis, Epilepsy Prognosis, and Treatment Resistance



Zachary O. Dent1, Liam Chen2, *
1 Department of Medicine, University of Minnesota, Medical School, Minneapolis, MN55455, United States
2 Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN55455, United States


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Creative Commons License
© 2023 Dent and Chen

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN55455, United States; E-mail: llchen@umn.edu


Abstract

Recently, more attention has been paid to identifying biomarkers for epilepsy to direct a more personalized treatment strategy, especially for patients who suffer from drug-resistant epilepsy which carries a much poorer prognosis. microRNA has emerged as an important and diverse type of biomarker that can participate in metabolic and cellular processes of the disease and, importantly, can be detected in patient’s serum. In this short review, we compile state-of-the-art evidence regarding miRNA-146a, a novel biomarker that shows high potential for studying epileptogenesis, monitoring disease progression, evaluating treatment response, and may even function as a therapeutic target given its role in the process of neuroinflammation.

Keywords: microRNA-146a, Epileptogenesis, Epilepsy prognosis, Neuroinflammation, Biomarker, Drug-resistant epilepsy.