RESEARCH ARTICLE
Lipid Profiles as Markers for the Severity of Liver Diseases in Cirrhotic Patients
Rehab Badawi1, Mohamed Zakaria Abu Rahma2, Haidi K. Ramadan2, Shaimaa Soliman3, Dina A. Mohareb4, Nehad Hawash1, Rania Elkafoury1, Sherief Abd-Elsalam1, *
Article Information
Identifiers and Pagination:
Year: 2021Volume: 11
First Page: 93
Last Page: 98
Publisher ID: TOBIOMJ-11-93
DOI: 10.2174/1875318302111010093
Article History:
Received Date: 19/2/2021Revision Received Date: 26/7/2021
Acceptance Date: 23/8/2021
Electronic publication date: 17/11/2021
Collection year: 2021
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background
Liver cirrhosis is a diffuse process in which the anatomical structure and function of the liver are disturbed. Lipid metabolism occurs mainly in the hepatocytes. In liver cirrhosis, it is expected to detect abnormal lipid profile and abnormal neutrophil to lymphocyte ratio due to necro-inflammation and hepatocyte dysfunction. This study aimed to estimate the lipid profile in patients with liver cirrhosis and to assess its relation to the severity of the liver disease based on Child-Pugh Turcotte score and Neutrophil to Lymphocyte Ratio (NLR).
Methods:
This study included 500 cirrhotic patients. All patients are subjected to history taking, clinical examination, liver and renal function tests, lipid profile, and also abdomino-pelvic ultrasound. Child -Pugh score, fibrosis-4 score (FIB4), and neutrophil and platelet lymphocyte ratio were calculated.
Results:
A total of 500 patients were enrolled in this study; 12 patients were excluded (two patients were on the immunosuppressive drug, three patients had body mass index (BMI) >30, and seven patients took lipid-lowering drugs). Cholesterol level was significantly higher in patients with Child- Score A than B and C. Cholesterol, Low-Density Lipoprotein (LDL), and very-low-density lipoprotein (VLDL) cholesterol were significantly higher in Child B than C. A significant negative correlation was found between cholesterol level and each of FIB4 and NLR ratios.
Conclusion:
There was a significant negative correlation between the severity of liver cirrhosis and lipid profiles (except triglyceride), FIB4 and NLR ratio.