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Urinary Biomarkers of Oxidative Stress in Atrial Fibrillation



Lei Mengǂ, 1, Ricko Wongǂ, 2, Man Yin Tsui3, Gary Tse4, 5, Guangping Li1, Tong Liu*, 1, Gregory Y. H. Lip6
1 Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin300211, P.R. China
2 Faculty of Medicine, The University of Notre Dame, Perth, Australia
3 Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, P.R. China
4 Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, SAR, P.R. China
5 Li Ka Shing Institute of Health Sciences, 30-32 Ngan Shing St, Chinese University of Hong Kong, Hong Kong, SAR, P.R. China
6 University of Birmingham Institute of Cardiovascular Sciences, City Hospital, BirminghamB18 7QH, United Kingdom


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© 2018 Meng et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People’s Republic of China, Tel: +86-22-88328368; Fax: +86-22-28261158. E-mail: liutongdoc@126.com
ǂ The first two authors contribute equally to this work.


Abstract

There is increasing evidence from molecular studies to support the role of inflammation and increased oxidative stress that produce structural and electrical atrial remodeling to produce Atrial Fbrillation (AF). Oxidative damage to cardiomyocytes yields chemical substances that are secreted in urine. These substances can serve as biomarkers that can be measured, potentially allowing clinicians to quantify oxidative damage to the heart.

Keywords: Atrial fibrillation, Oxidative stress, Urinary biomarkers, Inflammation, CRP, IL-6, Isoprostanes, 8-OHdG, Antioxidant, NADPH oxidase.