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Urinary Biomarkers of Oxidative Stress in Atrial Fibrillation
Lei Meng, 1
Ricko Wong, 2
Man Yin Tsui3
Gary Tse4 , 5
Guangping Li1
Tong Liu, *
, 1
Gregory Y. H. Lip6
Authors Info & Affiliations
, 1
Gregory Y. H. Lip6
Authors Info & Affiliations
Abstract
There is increasing evidence from molecular studies to support the role of inflammation and increased oxidative stress that produce structural and electrical atrial remodeling to produce Atrial Fbrillation (AF). Oxidative damage to cardiomyocytes yields chemical substances that are secreted in urine. These substances can serve as biomarkers that can be measured, potentially allowing clinicians to quantify oxidative damage to the heart.
Keywords: Atrial fibrillation, Oxidative stress, Urinary biomarkers, Inflammation, CRP, IL-6, Isoprostanes, 8-OHdG, Antioxidant, NADPH oxidase.
