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Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure
Queen Henry-Okafor1
Sean P. Collins2
Cathy A. Jenkins1
Karen F. Miller1
David J. Maron1
Allen J. Naftilan1
Neal Weintraub3
Gregory J. Fermann2
John McPherson1
Santosh Menon4
Douglas B. Sawyer1
Alan B. Storrow1 , *
Authors Info & Affiliations
Authors Info & Affiliations
Abstract
Objectives:
We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF).
Methods:
We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses.
Results:
Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results.
Conclusion:
Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility
Keywords: Acute heart failure, uric acid, b-type natriuretic peptide, prognostic outcomes.
