RESEARCH ARTICLE


Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure



Queen Henry-Okafor1, Sean P. Collins2, Cathy A. Jenkins1, Karen F. Miller1, David J. Maron1, Allen J. Naftilan1, Neal Weintraub3, Gregory J. Fermann2, John McPherson1, Santosh Menon4, Douglas B. Sawyer1, Alan B. Storrow1, *
1 Department of Cardiovascular Medicine, Department of Emergency Medicine and the Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA
2 Department of Emergency Medicine, University of Cincinnati, OH, USA
3 Division of Cardiology, Department of Internal Medicine, University of Cincinnati, OH, USA
4 Department of Cardiovascular Medicine The Ohio Heart & Vascular Center, The Christ Hospital in Cincinnati, OH, USA


© 2012 Henry-Okafor et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Research and Academic Af-fairs Department of Emergency Medicine Vanderbilt University Medical Center 1313 21st Avenue, South 703 Oxford House Nashville, TN 37232-4700 USA; Tel: (615) 936-5934; Fax: (615) 936-4490; E-mail: alan.b.storrow@vanderbilt.edu


Abstract

Objectives:

We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF).

Methods:

We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses.

Results:

Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results.

Conclusion:

Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility

Keywords: Acute heart failure, uric acid, b-type natriuretic peptide, prognostic outcomes.