Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure

Queen Henry-Okafor1, Sean P. Collins2, Cathy A. Jenkins1, Karen F. Miller1, David J. Maron1, Allen J. Naftilan1, Neal Weintraub3, Gregory J. Fermann2, John McPherson1, Santosh Menon4, Douglas B. Sawyer1, Alan B. Storrow1, *
1 Department of Cardiovascular Medicine, Department of Emergency Medicine and the Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA
2 Department of Emergency Medicine, University of Cincinnati, OH, USA
3 Division of Cardiology, Department of Internal Medicine, University of Cincinnati, OH, USA
4 Department of Cardiovascular Medicine The Ohio Heart & Vascular Center, The Christ Hospital in Cincinnati, OH, USA

© 2012 Henry-Okafor et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Research and Academic Af-fairs Department of Emergency Medicine Vanderbilt University Medical Center 1313 21st Avenue, South 703 Oxford House Nashville, TN 37232-4700 USA; Tel: (615) 936-5934; Fax: (615) 936-4490; E-mail:



We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF).


We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses.


Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results.


Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility

Keywords: Acute heart failure, uric acid, b-type natriuretic peptide, prognostic outcomes.