Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure
Queen Henry-Okafor1, Sean P. Collins2, Cathy A. Jenkins1, Karen F. Miller1, David J. Maron1, Allen J. Naftilan1, Neal Weintraub3, Gregory J. Fermann2, John McPherson1, Santosh Menon4, Douglas B. Sawyer1, Alan B. Storrow1, *
Identifiers and Pagination:Year: 2012
First Page: 9
Last Page: 15
Publisher Id: TOBIOMJ-5-9
Article History:Received Date: 28/02/2012
Revision Received Date: 25/04/2012
Acceptance Date: 30/04/2012
Electronic publication date: 13/7/2012
Collection year: 2012
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF).
We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses.
Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results.
Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility