Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure

Henry-Okafor, Queen; P. Collins, Sean; A. Jenkins, Cathy; F. Miller, Karen; J. Maron, David; J. Naftilan, Allen; Weintraub, Neal; J. Fermann, Gregory; McPherson, John; Menon, Santosh; B. Sawyer, Douglas; B. Storrow, Alan

Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure

Queen Henry-Okafor¹, Sean P. Collins², Cathy A. Jenkins¹, Karen F. Miller¹, David J. Maron¹, Allen J. Naftilan¹, Neal Weintraub³, Gregory J. Fermann², John McPherson¹, Santosh Menon⁴, Douglas B. Sawyer¹, Alan B. Storrow^{1, *}

¹ Department of Cardiovascular Medicine, Department of Emergency Medicine and the Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA

² Department of Emergency Medicine, University of Cincinnati, OH, USA

³ Division of Cardiology, Department of Internal Medicine, University of Cincinnati, OH, USA

⁴ Department of Cardiovascular Medicine The Ohio Heart & Vascular Center, The Christ Hospital in Cincinnati, OH, USA

Article Information

Identifiers and Pagination:

Year: 2012
Volume: 5
First Page: 9
Last Page: 15
Publisher ID: TOBIOMJ-5-9
DOI: 10.2174/1875318301205010009

Article History:

Received Date: 28/02/2012
Revision Received Date: 25/04/2012
Acceptance Date: 30/04/2012
Electronic publication date: 13/7/2012
Collection year: 2012

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© 2012 Henry-Okafor et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

^* Address correspondence to this author at the Research and Academic Af-fairs Department of Emergency Medicine Vanderbilt University Medical Center 1313 21st Avenue, South 703 Oxford House Nashville, TN 37232-4700 USA; Tel: (615) 936-5934; Fax: (615) 936-4490; E-mail: alan.b.storrow@vanderbilt.edu

Objectives:

We evaluated the association of plasma uric acid alone and in combination with b-type natriuretic peptide (BNP) for emergency department (ED) diagnosis and 30-day prognosis in patients evaluated for acute heart failure (AHF).

Methods:

We prospectively enrolled 322 adult ED patients with suspected AHF. Wilcoxon rank sum test, multivariable logistic regression and likelihood ratio (LR) tests were used for statistical analyses.

Results:

Uric acid's diagnostic utility was poor and failed to show significant associations with 30-day clinical outcomes. Uric acid also did not add significantly to BNP results.

Conclusion:

Among ED patients with suspected AHF, uric acid has poor diagnostic and prognostic utility

Keywords: Acute heart failure, uric acid, b-type natriuretic peptide, prognostic outcomes.

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RESEARCH ARTICLE

Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure

Article Information

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Abstract

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Methods:

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