RESEARCH ARTICLE


Indices Indicating Early Renal Microvascular Disease in Diabetes



N. Futrakul*, 1, P. Futrakul2
1 Renal Microcirculation Research Group, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
2 Academy of Science, The Royal Institute of Thailand


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© 2011 Futrakul

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Renal Microcirculation Research Group, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand; Tel: 60813511214; Fax: 022584267; E-mail: fmednft@yahoo.com


Abstract

Renal microvascular disease is crucial to renal disease progression. Renal microvascular disease in late stage diabetic nephropathy is associated with defective angiogenesis and fails to respond to vasodilator treatment. Recognition of early renal microvascular disease is necessary, since in this stage, the vascular homeostasis is adequately functional and responsive to vasodilator treatment. Indices that can screen early renal microvascular disease include creatinine clearance or glomerular filtration rate, renal plasma flow or peritubular capillary flow and fractional excretion of magnesium (FE Mg).

Keywords: Renal microvascular disease, Diabetes, Vascular homeostasis, Renal hemodynamics, FE Mg.