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RESEARCH ARTICLE

Indices Indicating Early Renal Microvascular Disease in Diabetes

N. Futrakul, * Open Modal , 1 P. Futrakul2 Authors Info & Affiliations
The Open Biomarkers Journal • 28 December 2011 • RESEARCH ARTICLE • DOI: 10.2174/1875318301104010018

Abstract

Renal microvascular disease is crucial to renal disease progression. Renal microvascular disease in late stage diabetic nephropathy is associated with defective angiogenesis and fails to respond to vasodilator treatment. Recognition of early renal microvascular disease is necessary, since in this stage, the vascular homeostasis is adequately functional and responsive to vasodilator treatment. Indices that can screen early renal microvascular disease include creatinine clearance or glomerular filtration rate, renal plasma flow or peritubular capillary flow and fractional excretion of magnesium (FE Mg).

Keywords: Renal microvascular disease, Diabetes, Vascular homeostasis, Renal hemodynamics, FE Mg.
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