Lipoprotein Lipase and Neurological Health: Investigating its Impact on Brain Function and Alzheimer's Disease

Abstract

Lipoprotein Lipase (LPL) is an essential lipid metabolism enzyme affecting both the brain and peripheral tissues. Its impact on neuronal lipid homeostasis, synaptic function, and plasticity is increasingly recognized. This review explores the various functions of LPL in the brain and how it may affect neurological health, especially in Alzheimer's disease. We explore how LPL regulates lipid uptake and utilization in the brain, its influence on synaptic function, neurogenesis, and myelination, and its role in the pathophysiology of AD. Genetic and environmental factors modulating LPL activity are also discussed. The review provides insights into LPL's role in neurodegenerative diseases, acknowledges current limitations and challenges in research, and highlights the therapeutic potential of targeting LPL for AD treatment. Ultimately, this review underscores the importance of LPL in maintaining brain health and its promising potential as a therapeutic target for AD.