RESEARCH ARTICLE


Role of Serum Cystatin C as a Diagnostic Tool for Renal Function in Cirrhotic Patients



Fathia Elsayed Asal1, Mohamed Yousef1, Hend Atteya Abdelkhalek Abdraboh1, Sherief Abd-Elsalam1, *, Ahmed Abdelaziz Abdelaziz Shama2, Mohamed Elbahnasawy3, Mohammed H Elnaggar4, Hesham Ahmed Alsrogy5, Heba Elashry1
1 Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, Tanta, Egypt
2 Department of Anesthesia, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt
3 Department of Emergency Medicine and Traumatology, Faculty of Medicine, Tanta University, Tanta, Egypt
4 Department of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt
5 Department of Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt


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Creative Commons License
© 2022 Asal et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University. El-Giash Street 31527, Tanta, Egypt; Tel: +2-01147773440; E-mails: sherif.abdelbaky@med.tanta.edu.eg, sherif_tropical@yahoo.com


Abstract

Background:

Assessment of cystatin C levels could be valuable in the early detection of renal dysfunction because they increase faster than the creatinine levels as the GFR decreases. The aim of this work was to evaluate serum cystatin C as a diagnostic tool for renal dysfunction in cirrhotic patients with and without hepatorenal syndrome (HRS).

Methods:

This case-control study was conducted on 60 patients from the Tropical Medicine Department of Tanta University Hospitals and 10 people served as healthy control volunteers. Serum cystatin C was measured in the three groups.

Results:

A significant difference was observed among the three groups as cystatin C was higher in patients with HRS compared to the cirrhotic group and healthy controls.

Conclusion:

Serum cystatin C is a good predictor for hepatorenal syndrome with a good correlation with serum creatinine, blood urea, GFR, and creatinine clearance.

Keywords: Cirrhosis, Kidney, Liver, Renal functions, Liver failure, Marker.