RESEARCH ARTICLE

Epidermal Growth Factor rs4444903 A>G Gene Polymorphism Association with Chronic Hepatitis B Liver Disease Progression among Egyptian Children: A Multicenter Study

Amal A. Mohamed1 Gehan L.A. Hakeem2 Gihan M. Babrs2 Laila E. Abolfotoh2 Nageh M. Shehata2 Sheren E. Maher2 Suzan M. Mousa2 Ahlam M. Ismail3 Doaa Ezzat4 Ahmed G.K. Habib5 Doaa M. Ghaith6 Naglaa Fawazy7 Rania A. Khattab8 Eman El S. Habib9 Dalia M. Abd El-Hassib10 Sherief Abd-Elsalam11 , * Open Modal Dalia A. El-damasy12 Authors Info & Affiliations
The Open Biomarkers Journal 12 July 2021 RESEARCH ARTICLE DOI: 10.2174/1875318302111010063

Abstract

Background:

Polymorphisms of genes encoding the pro-inflammatory and anti-inflammatory cytokines can affect the clinical presentation of the infection. We aimed to assess the role of EGF gene single-nucleotide polymorphism in the outcome of chronic hepatitis B virus (HBV) infection in children.

Methods:

One hundred HBV-infected children and 75 healthy matched controls were enrolled in this prospective study. Patients included 18 chronic inactive and 82 chronic active carriers. EGF rs4444903 A>G genotypes were determined using allele-specific amplification.

Results:

Significant differences regarding EGF genotypic frequency (p=0.001) in patients compared to controls (p=0.001). Eighteen percent were inactive, and 82% were active carriers. AA, AG and GG genotypic frequency were 66.7%, 33.3%, 0% and were 3.7%, 37.8% and 58.5% in the inactive and active carriers, respectively, with significant differences regarding AA, AG, GG genotypic frequency (p=0.001 for all). EGF AA, AG, GG genotypes frequency were 1.9%, 33.3%, and 64.8%, respectively, with significant differences between cirrhotic and non-cirrhotic patients regarding AA, AG, GG genotypic frequency (p=0.001 for all).

Conclusion:

Increased G allele frequency in EGF rs4444903 A > G polymorphism in HBV- Egyptian children is associated with worse outcomes.

Keywords: HBV, Carriers , Cirrhosis , EGF , Polymorphism , Egyptian children .
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