Clinical Investigation: Determinants of Blood Cell Omega-3 Fatty Acid Content
Robert C. Blocka, *, William S. Harris b, James V. Pottala b
Identifiers and Pagination:Year: 2008
First Page: 1
Last Page: 6
Publisher Id: TOBIOMJ-1-1
Article History:Received Date: 24/03/2008
Revision Received Date: 28/04/2008
Acceptance Date: 13/06/2008
Electronic publication date: 29/08/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Although red blood cell eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) content (the Omega-3 Index) predicts cardiovascular death, the factors determining the Index are unknown.
In 704 outpatients, we undertook an investigation of the clinical determinants of the Index.
Factors associated with the Index in decreasing order were: EPA+DHA supplement use, fish consumption frequency, triglyceride level, age, high cholesterol history, and smoking. These factors explained 59% of Index variability, with capsules/fish intake together accounting for 47%. The Index increased by 13% (p< 0.0001) for each serving level increase in fish intake and EPA+DHA supplementation correlated with a 58% increase (p< 0.0001) regardless of background fish intake (p=0.25; test for interaction). A 100 mg/dL decrease in serum triglycerides was associated with a 15% higher (p<0.0001) Index.
The intake of EPA+DHA-rich foods and supplements principally determined the Omega-3 Index, but explained only about half of the variability.