Applications of Different Biomarkers in the Diagnosis of Drug-induced Liver Injury



Monika Sharma1, Ishita Yadav1, Chandra Kant Sharma2, *
1 Deptt. of Bioscience and Biotechnology Banasthali Vidyapith, Banasthali, Rajasthan, India-304022
2 SAGE University, Indore, Madhya Pradesh, India-452020

Abstract

Biomarkers perform a significant function in the process of drug development. Biomarkers have been utilized in the safety assessment of drugs in clinical practice and also for personalization of medicines. To recognize the relation among considerable biological processes as well as clinical outcomes, it is important to increase our potential of treatments for all ailments, in addition to our understanding of normal and healthy physiology. Since the 1980s, using biomarkers is essential for substitutional results in long term assessments of main maladies, for example, cancer, as well as illness related to the heart. Now a days, biomarkers are highly important for unifying discovery of the drug and day by day improvements. The importance of biomarkers is increasing gradually with the advancement of novel therapeutics for the treatment and prevention of a broad range of diseases in order to overcome hepatotoxicity. These biomarkers are extensively used for the identification of disease and the field of medical research. The use of biomarkers in clinical as well as basic research has been promoted rapidly by the different drug regulation authorities for better outcomes in the future.

Keywords: Biomarkers, Drug development, Diagnosis.


Abstract Information


Identifiers and Pagination:

Year: 2019
Volume: 9
Publisher Item Identifier: EA-TOBIOMJ-2019-HT1-699-2

Article History:

Received Date: 27/03/2019
Revision Received Date: 09/05/2019
Acceptance Date: 20/05/2019
Electronic publication date: 23/08/2019
Collection year: 2019

© 2019 Sharma et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at: SAGE University, Indore, Madhya Pradesh, India-452020; E-mail: ck21sharma@rediffmail.com