Urinary Biomarkers of Oxidative Stress in Atrial Fibrillation
Lei Mengǂ, 1, Ricko Wongǂ, 2, Man Yin Tsui3, Gary Tse4, 5, Guangping Li1, Tong Liu*, 1, Gregory Y. H. Lip6
There is increasing evidence from molecular studies to support the role of inflammation and increased oxidative stress that produce structural and electrical atrial remodeling to produce Atrial Fbrillation (AF). Oxidative damage to cardiomyocytes yields chemical substances that are secreted in urine. These substances can serve as biomarkers that can be measured, potentially allowing clinicians to quantify oxidative damage to the heart.
* Address correspondence to this author at the Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People’s Republic of China, Tel: +86-22-88328368; Fax: +86-22-28261158. E-mail: email@example.comǂ The first two authors contribute equally to this work.